Booth Multiplier Based on Low Power High Speed Full Adder With Fin_FET Technology

This paper proposes a novel Fin FET-based HSFA for the multiplier in order to overcome the issues of low speed operation. It is advantageous to use Fin FETs to construct the arithmetic circuit while assessing the available works. The carry propagation and slow operation of the old technique are disadvantages. The CMOS-based compressor circuit, on the other hand, suffers from leakage current, which reduces its driving capabilities. High current DSP applications are well matched to the design's specifications. Even with a supply voltage of 1 volt, the proposed device has a decent driving capability. As a result, the circuit runs more quickly and has less latency. A transmission gate is used in the design of the suggested adder structure to selectively block or transfer data from the input to output. Half adder and adder are shown in the following illustrations. The smaller the transistor count, the less power it uses. The suggested Fin FET design for the smaller transistors has a superior driving capability than the CMOS equivalent. Additionally, when cascading, the Fin FET based adder may contribute to superior switch performance, such as when using ripple carry adder. There is also the possibility of a low operation, which may operate at Low wattage Electronic designs for high-performance and small devices have become increasingly dependent on the use of VLSI circuits. The power of a processor is determined in large part by the multiplier used in its design. Multiplier factor booth coding is being used to reorder the input bits in order to reduce facility use. The booth decoder works by rearranging the specified booth equivalent. The Booth decoder has the ability to expand the range of zeros. As a result, the power consumption of the design will be decreased even more. As soon as the input bit constant drops below zero, related rows or columns of an adder must be disabled, if possible

Void Node Detection and Packet Re-routing in Underwater Wireless Sensor Network

Underwater wireless sensor networks (UWSNs) have been appeared as an encouraging innovation to screen and investigate the seas in lieu of customary undersea wire line instruments. All things considered, the information social occasion of UWSNs is still seriously restricted in light of the acoustic channel correspondence attributes. One approach to improve the information assortment in UWSNs is through the plan of directing conventions thinking about the special attributes of the underwater acoustic correspondence and the exceptionally unique organization geography. In this paper, we propose the GEDAR steering convention for UWSNs. GEDAR is an anycast, geographic and deft steering convention that courses information parcels from sensor hubs to numerous sonobuoys (sinks) at the ocean's surface. At the point when the hub is in a correspondence void area, GEDAR changes to the recuperation mode strategy which depends on geography control through the profundity change of the void hubs, rather than the customary methodologies utilizing control messages to find and keep up steering ways along void locales. Reproduction results show that GEDAR altogether improves the organization execution when contrasted and the pattern arrangements, even in hard and troublesome versatile situations of inadequate and extremely thick networks and for high organization traffic loads

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990–2010 time period, with the greatest annualised rate of decline occurring in the 0–9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10–24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10–24 years were also in the top ten in the 25–49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50–74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation: As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and developm nt investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens

The Legalization of Cannabis in California: Contested Meanings and Ideational Change

California occupies a special place in cannabis policy. It was the first state to prohibit recreational use of cannabis in 1913 and the first to allow its medical use in 1996. In 2016, California passed Proposition 64 that permitted recreational use of cannabis and had record public support rates —57%. However, the acceptance of cannabis did not arise with the same intensity across California. Counties and cities have discretion over deciding whether to allow or forbid cannabis companies within their borders, and many are still debating. In 2016, two-third of California cities supported the legalization of recreational use of cannabis. As of now, only one-third of local jurisdictions permitted the distribution, cultivation, testing, manufacturing, or sale of cannabis. Others have passed ordinances forbidding any cannabis-related economic activities within their borders. The case of cannabis legalization presents an ideal context to unpack the complex relationship between legality and legitimacy. One can expect that placing cannabis in a context of increasing legality will contribute to its legitimacy, i.e., dismantle old stereotypes and remove cannabis from the context of criminal justice. However, the idea of “legal cannabis” is not yet crystalized and remains in a liminal state. There is no consensus about what cannabis is and what it is not. Cannabis is a pain-relief medicine that is not available at the pharmacy and a recreational intoxicant that cannot be purchased at the supermarket (unlike wine, beer, or tobacco. This project looks at the adoption of cannabis regulation as an example of morality policies, through which local governments draw a boundary between “pure” and “polluted,” “ordered” and “disordered,” “safe” and “dangerous” places. The question is not whether cannabis is legal in California but where, how, and to what degree it is legal. Legalization is not something that happens overnight; it is a gradual process of social and cultural transformation that started in California well before the passage of Proposition 64 in 2016 and may extend long into the future. Therefore, I adopt a process-oriented approach, which allows us to speak about legalizing cannabis in California as a project under construction

Research in Progress: A Report Researching Indigenous Australian Success in Higher Education: A Case-Study of an Australian University

The article presents a case study of the success of Indigenous Australians in higher education. The author identifies the issues and the gaps of knowledge in the area of minority student performance in higher education, the academic success of the Indigenous, and its contributing factors. She also investigates the average Indigenous enrolment and completion numbers and completion rates from Australian universities over the period of seven years, from 2004 to 2010

Public Hospitals in China: Is There a Variation in Patient Experience with Inpatient Care

In China, public hospitals are the main provider of inpatient service. The Chinese public hospital reform has recently shifted towards health care organizations and delivery to improve health care quality. This study analyzes the variation of one of the dimensions of health care quality, patient-centeredness, among inpatients with different socioeconomic status and geographical residency in China. 1471 respondents who received inpatient care in public hospitals were included in our analysis. Patient-centeredness performance was assessed on the dimensions of Communication, Autonomy, Dignity, and Confidentiality. Variations of inpatient experience were estimated using binary logistic regression models according to: residency, region, age, gender, education, income quintile, self-rated health, and number of hospital admissions. Our results indicate that older patients, and patients living in rural areas and Eastern China are more likely to report positive experience of their public hospital stay according to the care aspects of Dignity, Communication, Confidentiality and Autonomy. However, there remains a gap between China and other countries in relation to inpatient experience. Noticeable disparities in inpatient experience also persist between different geographical regions in China. These variations of patient experience pose a challenge that China’s health policy makers would need to consider in their future reform efforts

Evaluating Primary Health Care Performance from User Perspective in China: Review of Survey Instruments and Implementation Issues

This review aims to summarize the progress of patient evaluation studies focusing on primary health care (PHC) in China, specifically in relation to survey instruments and implementation issues. Eligible studies published in English or Chinese were obtained through online searches of PubMed and China National Knowledge Infrastructure. A descriptive reporting approach was used due to variations in the measurements and administration methods between studies. A total of 471 articles were identified and of these articles; of those 91 full-text articles were included in the final analysis. Most studies used author-developed measurements with five-point Likert response scales and many used the Chinese translations of validated tools from other countries. Most instruments assessed the physical environment, medical equipment, clinical competency and convenience aspects of PHC using a satisfaction rating instead of care experience reporting. Many studies did not report the sampling approach, patient recruitment procedures and survey administration modes. The patient exit survey was the most commonly used survey implementation method. The focus on the structural dimensions of PHC, inconsistent wording, categories of response options that use satisfaction rating, and unclear survey implementation processes are common problems in patient evaluation studies of PHC in China. Further studies are necessary to identify population preferences of PHC in China in order to move towards developing Chinese value-based patient experience measurements

DGLA from the Microalga Lobosphaera Incsa P127 Modulates Inflammatory Response, Inhibits iNOS Expression and Alleviates NO Secretion in RAW264.7 Murine Macrophages

Microalgae have been considered as a renewable source of nutritional, cosmetic and pharmaceutical compounds. The ability to produce health-beneficial long-chain polyunsaturated fatty acids (LC-PUFA) is of high interest. LC-PUFA and their metabolic lipid mediators, modulate key inflammatory pathways in numerous models. In particular, the metabolism of arachidonic acid under inflammatory challenge influences the immune reactivity of macrophages. However, less is known about another omega-6 LC-PUFA, dihomo-γ-linolenic acid (DGLA), which exhibits potent anti-inflammatory activities, which contrast with its delta-5 desaturase product, arachidonic acid (ARA). In this work, we examined whether administrating DGLA would modulate the inflammatory response in the RAW264.7 murine macrophage cell line. DGLA was applied for 24 h in the forms of carboxylic (free) acid, ethyl ester, and ethyl esters obtained from the DGLA-accumulating delta-5 desaturase mutant strain P127 of the green microalga Lobosphaera incisa. DGLA induced a dose-dependent increase in the RAW264.7 cells’ basal secretion of the prostaglandin PGE1. Upon bacterial lipopolysaccharide (LPS) stimuli, the enhanced production of pro-inflammatory cytokines, tumor necrosis factor alpha (TNFα) and interleukin 1β (IL-1β), was affected little by DGLA, while interleukin 6 (IL-6), nitric oxide, and total reactive oxygen species (ROS) decreased significantly. DGLA administered at 100 µM in all forms attenuated the LPS-induced expression of the key inflammatory genes in a concerted manner, in particular iNOS, IL-6, and LxR, in the form of free acid. PGE1 was the major prostaglandin detected in DGLA-supplemented culture supernatants, whose production prevailed over ARA-derived PGE2 and PGD2, which were less affected by LPS-stimulation compared with the vehicle control. An overall pattern of change indicated DGLA’s induced alleviation of the inflammatory state. Finally, our results indicate that microalgae-derived, DGLA-enriched ethyl esters (30%) exhibited similar activities to DGLA ethyl esters, strengthening the potential of this microalga as a potent source of this rare anti-inflammatory fatty acid

Втора научна сесия за преподаватели и студенти 3-4 Октомври 2013, Варна

Варненски медицински форум (Varna Medical Forum) V. 2, Suppl 3(2013